Drug interactions
Atazanavir + Ifosfamide
Severity: Moderate
Atazanavir and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug activated mainly by CYP3A4 and CYP2B6, and also inactivated via N-dechloroethylation by CYP3A4 producing neurotoxic chloroacetaldehyde. Atazanavir inhibits CYP3A4 and may change the balance of active and toxic metabolites, with uncertain clinical effect.
What this interaction means in plain words
Atazanavir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Ifosfamide belongs to Oncology.
Why it happens
CYP3A4 inhibition by atazanavir alters ifosfamide metabolism and may reduce formation of active metabolites.
What to do
Monitor for reduced response and for neurotoxicity or other toxicity. Consider an alternative antiretroviral without CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Ifosfamide?
MediHelp rates the interaction as moderate. Atazanavir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a prodrug activated mainly by CYP3A4 and CYP2B6, and also inactivated via N-dechloroethylation by CYP3A4 producing neurotoxic chloroacetaldehyde. Atazanavir inhibits CYP3A4 and may change the balance of active and toxic metabolites, with uncertain clinical effect.
How serious is the interaction between Atazanavir and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for neurotoxicity or other toxicity. Consider an alternative antiretroviral without CYP3A4 inhibition if feasible.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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