Drug interactions
Atazanavir + Insulin degludec
Severity: Moderate
Atazanavir and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effect of insulin degludec. Atazanavir is among the protease inhibitors with less metabolic impact, but glucose control may still change.
What this interaction means in plain words
Atazanavir and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Insulin degludec belongs to Endocrine.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose uptake, opposing the effect of insulin.
What to do
Monitor glucose and HbA1c after starting or changing protease inhibitor therapy and increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Insulin degludec?
MediHelp rates the interaction as moderate. Atazanavir and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effect of insulin degludec. Atazanavir is among the protease inhibitors with less metabolic impact, but glucose control may still change.
How serious is the interaction between Atazanavir and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or changing protease inhibitor therapy and increase the insulin dose as needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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