Drug interactions
Atazanavir + Levonorgestrel
Severity: Minor
Atazanavir and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir may alter levonorgestrel exposure, most likely increasing it through CYP3A4 inhibition. With an intrauterine system systemic exposure is low, so the effect is of limited clinical concern.
What this interaction means in plain words
Atazanavir and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Levonorgestrel belongs to Endocrine.
Why it happens
CYP3A4 inhibition by atazanavir may reduce levonorgestrel metabolism.
What to do
No change is generally needed with an intrauterine system; for oral levonorgestrel monitor for adverse effects or consider alternatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Levonorgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levonorgestrel
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Levonorgestrel?
MediHelp rates the interaction as minor. Atazanavir and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir may alter levonorgestrel exposure, most likely increasing it through CYP3A4 inhibition. With an intrauterine system systemic exposure is low, so the effect is of limited clinical concern.
How serious is the interaction between Atazanavir and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is generally needed with an intrauterine system; for oral levonorgestrel monitor for adverse effects or consider alternatives.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
