Drug interactions
Atazanavir + Metformin-repaglinide
Severity: Moderate
Atazanavir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise repaglinide levels, increasing hypoglycemia risk. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of the antidiabetic therapy.
What this interaction means in plain words
Atazanavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
CYP3A4 inhibition by atazanavir reduces repaglinide clearance, while protease inhibitor therapy can induce insulin resistance.
What to do
Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs; reassess glycemic control over time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Atazanavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may raise repaglinide levels, increasing hypoglycemia risk. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of the antidiabetic therapy.
How serious is the interaction between Atazanavir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs; reassess glycemic control over time.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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