Drug interactions
Atazanavir + Nilotinib
Severity: Major
Atazanavir and Nilotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and raises nilotinib exposure. Atazanavir also prolongs PR and sometimes QT interval, so the combination increases the risk of QT-related arrhythmia.
What this interaction means in plain words
Atazanavir and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated nilotinib metabolism, plus additive effects on cardiac conduction.
What to do
Avoid the combination where possible and choose an antiretroviral without strong CYP3A4 inhibition. If it is unavoidable, reduce the nilotinib dose per labeling and monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Nilotinib?
MediHelp rates the interaction as major. Atazanavir and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and raises nilotinib exposure. Atazanavir also prolongs PR and sometimes QT interval, so the combination increases the risk of QT-related arrhythmia.
How serious is the interaction between Atazanavir and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antiretroviral without strong CYP3A4 inhibition. If it is unavoidable, reduce the nilotinib dose per labeling and monitor ECG and electrolytes closely.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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