Drug interactions
Atazanavir + Pioglitazone
Severity: Minor
Atazanavir and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which is a minor pathway for pioglitazone, so exposure may rise slightly. The effect is generally small, though fluid retention and glucose lowering could be slightly enhanced.
What this interaction means in plain words
Atazanavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 modestly reduces pioglitazone clearance.
What to do
No empirical dose change is needed. Monitor for edema and glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Pioglitazone?
MediHelp rates the interaction as minor. Atazanavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4, which is a minor pathway for pioglitazone, so exposure may rise slightly. The effect is generally small, though fluid retention and glucose lowering could be slightly enhanced.
How serious is the interaction between Atazanavir and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for edema and glycemic response.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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