Drug interactions
Atazanavir + Praziquantel
Severity: Moderate
Atazanavir and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which is the main route of praziquantel metabolism, and may raise praziquantel concentrations. This could increase dose-related adverse effects such as dizziness, headache and abdominal discomfort.
What this interaction means in plain words
Atazanavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Praziquantel belongs to Anti Parasitic.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of praziquantel.
What to do
Standard dosing is usually acceptable for short courses. Monitor for increased adverse effects such as dizziness and drowsiness and counsel patients to avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Praziquantel?
MediHelp rates the interaction as moderate. Atazanavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4, which is the main route of praziquantel metabolism, and may raise praziquantel concentrations. This could increase dose-related adverse effects such as dizziness, headache and abdominal discomfort.
How serious is the interaction between Atazanavir and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Standard dosing is usually acceptable for short courses. Monitor for increased adverse effects such as dizziness and drowsiness and counsel patients to avoid driving.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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