Drug interactions
Atazanavir + Prednisolone
Severity: Moderate
Atazanavir and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, boosted or not, inhibits CYP3A4 and may raise prednisolone exposure. Effect is modest compared with that on more CYP3A4-dependent steroids, but systemic corticosteroid effects can increase with long-term use.
What this interaction means in plain words
Atazanavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Prednisolone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by atazanavir reduces prednisolone metabolism.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression during extended therapy, and reduce the prednisolone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Prednisolone?
MediHelp rates the interaction as moderate. Atazanavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, boosted or not, inhibits CYP3A4 and may raise prednisolone exposure. Effect is modest compared with that on more CYP3A4-dependent steroids, but systemic corticosteroid effects can increase with long-term use.
How serious is the interaction between Atazanavir and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression during extended therapy, and reduce the prednisolone dose if they occur.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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