Drug interactions
Atazanavir + Repaglinide
Severity: Moderate
Atazanavir and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may increase repaglinide concentrations, raising the risk of hypoglycemia. Ritonavir or cobicistat boosting may add to the effect.
What this interaction means in plain words
Atazanavir and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by atazanavir reduces repaglinide metabolism.
What to do
Monitor blood glucose closely and use a lower repaglinide dose if hypoglycemia occurs when atazanavir is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Repaglinide?
MediHelp rates the interaction as moderate. Atazanavir and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may increase repaglinide concentrations, raising the risk of hypoglycemia. Ritonavir or cobicistat boosting may add to the effect.
How serious is the interaction between Atazanavir and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and use a lower repaglinide dose if hypoglycemia occurs when atazanavir is started.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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