Drug interactions
Atazanavir + Sofosbuvir-velpatasvir
Severity: Minor
Atazanavir and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir boosted with ritonavir or cobicistat may raise velpatasvir exposure through CYP3A4 and P-gp inhibition. The increase is not generally considered clinically significant, and the combination is commonly used in HIV/HCV coinfection. Tenofovir in the HIV regimen is the more relevant concern.
What this interaction means in plain words
Atazanavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Atazanavir inhibits CYP3A4 (and P-gp when boosted), which modestly reduces velpatasvir clearance.
What to do
No empiric dose change is needed. Monitor renal function if the regimen also contains tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Atazanavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir boosted with ritonavir or cobicistat may raise velpatasvir exposure through CYP3A4 and P-gp inhibition. The increase is not generally considered clinically significant, and the combination is commonly used in HIV/HCV coinfection. Tenofovir in the HIV regimen is the more relevant concern.
How serious is the interaction between Atazanavir and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor renal function if the regimen also contains tenofovir.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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