Drug interactions
Atazanavir + Sorafenib
Severity: Moderate
Atazanavir and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a CYP3A4 inhibitor and may raise sorafenib exposure. Sorafenib is only partly cleared by CYP3A4, so the effect is probably modest, but higher exposure could increase adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
What this interaction means in plain words
Atazanavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Atazanavir inhibits CYP3A4-mediated oxidative metabolism of sorafenib, which may reduce its clearance.
What to do
Monitor for sorafenib toxicity such as dermatologic reactions, hypertension and gastrointestinal effects. Reduce the dose or interrupt treatment per labeling if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Sorafenib?
MediHelp rates the interaction as moderate. Atazanavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a CYP3A4 inhibitor and may raise sorafenib exposure. Sorafenib is only partly cleared by CYP3A4, so the effect is probably modest, but higher exposure could increase adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
How serious is the interaction between Atazanavir and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as dermatologic reactions, hypertension and gastrointestinal effects. Reduce the dose or interrupt treatment per labeling if adverse reactions occur.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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