Drug interactions
Atazanavir + Timolol
Severity: Moderate
Atazanavir and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir can prolong the PR interval, and combining it with timolol may add to AV conduction delay and bradycardia. Atazanavir may also raise timolol exposure through CYP2D6 inhibition.
What this interaction means in plain words
Atazanavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Timolol belongs to Cardiovascular.
Why it happens
Additive negative dromotropic effects, plus possible reduction in CYP2D6-mediated timolol clearance.
What to do
Monitor heart rate, blood pressure and ECG, particularly PR interval, and reduce the timolol dose if bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Timolol?
MediHelp rates the interaction as moderate. Atazanavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir can prolong the PR interval, and combining it with timolol may add to AV conduction delay and bradycardia. Atazanavir may also raise timolol exposure through CYP2D6 inhibition.
How serious is the interaction between Atazanavir and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, particularly PR interval, and reduce the timolol dose if bradycardia or conduction delay occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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