Drug interactions
Atenolol + Ethinyl estradiol-drospirenone
Severity: Minor
Atenolol and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium through antimineralocorticoid action, and beta-blockers like atenolol can modestly impair potassium shift into cells. The combined effect is usually small but may matter in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Atenolol and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Additive hyperkalemic effects from aldosterone antagonism by drospirenone and reduced cellular potassium uptake from beta-blockade.
What to do
Check serum potassium in patients with renal impairment or on other potassium-raising drugs; routine monitoring is otherwise unnecessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Atenolol and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise serum potassium through antimineralocorticoid action, and beta-blockers like atenolol can modestly impair potassium shift into cells. The combined effect is usually small but may matter in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Atenolol and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with renal impairment or on other potassium-raising drugs; routine monitoring is otherwise unnecessary.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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