Drug interactions
Atenolol + Hydrochlorothiazide-lisinopril
Severity: Minor
Atenolol and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding atenolol to lisinopril and hydrochlorothiazide produces additive blood pressure lowering, which is often intentional but can cause hypotension and bradycardia. Thiazides may also modestly worsen glucose and lipid control in patients on beta-blockers.
What this interaction means in plain words
Atenolol and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms; thiazide metabolic effects may add to beta-blocker effects on glucose.
What to do
Monitor blood pressure and heart rate, and check glucose in diabetic patients. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol and Hydrochlorothiazide-lisinopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Atenolol and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Adding atenolol to lisinopril and hydrochlorothiazide produces additive blood pressure lowering, which is often intentional but can cause hypotension and bradycardia. Thiazides may also modestly worsen glucose and lipid control in patients on beta-blockers.
How serious is the interaction between Atenolol and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and check glucose in diabetic patients. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
