Drug interactions
Atenolol + Ivabradine
Severity: Moderate
Atenolol and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow heart rate, so combined use raises the risk of symptomatic bradycardia and conduction disturbance. The combination is used in heart failure and angina but requires care.
What this interaction means in plain words
Atenolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive heart rate reduction from If channel inhibition in the sinus node and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG, especially during titration, and reduce the ivabradine dose or stop it if resting heart rate falls persistently below 50 beats per minute or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Atenolol with Ivabradine?
MediHelp rates the interaction as moderate. Atenolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow heart rate, so combined use raises the risk of symptomatic bradycardia and conduction disturbance. The combination is used in heart failure and angina but requires care.
How serious is the interaction between Atenolol and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially during titration, and reduce the ivabradine dose or stop it if resting heart rate falls persistently below 50 beats per minute or symptoms occur.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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