Drug interactions
Atenolol + Losartan
Severity: Moderate
Atenolol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs lower blood pressure additively, and the combination is established in practice. Losartan may raise potassium and is contraindicated in pregnancy due to fetal toxicity.
What this interaction means in plain words
Atenolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; angiotensin receptor blockade reduces aldosterone, and beta-blockade reduces cellular potassium uptake.
What to do
Monitor blood pressure, potassium and renal function after initiation or dose changes, and avoid in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Atenolol with Losartan?
MediHelp rates the interaction as moderate. Atenolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs lower blood pressure additively, and the combination is established in practice. Losartan may raise potassium and is contraindicated in pregnancy due to fetal toxicity.
How serious is the interaction between Atenolol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function after initiation or dose changes, and avoid in pregnancy.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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