Drug interactions
Atenolol + Mefloquine
Severity: Moderate
Atenolol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can slow cardiac conduction and cause bradycardia, and beta-blockers have similar effects. Combined use may increase the risk of bradycardia or conduction block. Atenolol is not metabolized by the liver, so a metabolic interaction is unlikely.
What this interaction means in plain words
Atenolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic effects on heart rate and atrioventricular conduction.
What to do
Monitor heart rate and ECG, particularly at the start of therapy. Avoid the combination in patients with conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Mefloquine?
MediHelp rates the interaction as moderate. Atenolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can slow cardiac conduction and cause bradycardia, and beta-blockers have similar effects. Combined use may increase the risk of bradycardia or conduction block. Atenolol is not metabolized by the liver, so a metabolic interaction is unlikely.
How serious is the interaction between Atenolol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, particularly at the start of therapy. Avoid the combination in patients with conduction disease.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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