Drug interactions
Atenolol + Nabumetone
Severity: Moderate
Atenolol and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as nabumetone can blunt the blood pressure lowering effect of beta-blockers like atenolol, particularly with continued use. The effect is variable and usually modest, but can reduce blood pressure control in hypertensive patients.
What this interaction means in plain words
Atenolol and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins causes sodium and fluid retention and opposes the antihypertensive effect of the beta-blocker.
What to do
Monitor blood pressure when nabumetone is started or used for more than a week or so with atenolol. Use the lowest effective NSAID dose for the shortest time, and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Nabumetone?
MediHelp rates the interaction as moderate. Atenolol and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as nabumetone can blunt the blood pressure lowering effect of beta-blockers like atenolol, particularly with continued use. The effect is variable and usually modest, but can reduce blood pressure control in hypertensive patients.
How serious is the interaction between Atenolol and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when nabumetone is started or used for more than a week or so with atenolol. Use the lowest effective NSAID dose for the shortest time, and adjust antihypertensive therapy if control worsens.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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