Drug interactions
Atenolol-chlorthalidone + Calcium gluconate
Severity: Moderate
Atenolol-chlorthalidone and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium salts can reduce atenolol absorption, which may modestly weaken its heart rate and blood pressure effects. Thiazide-like diuretics such as chlorthalidone reduce urinary calcium excretion, so with calcium supplements they can cause hypercalcemia.
What this interaction means in plain words
Atenolol-chlorthalidone and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Calcium may reduce atenolol gastrointestinal absorption, and chlorthalidone decreases renal calcium clearance, raising serum calcium.
What to do
Separate atenolol and oral calcium doses by at least 2 hours and monitor blood pressure and heart rate. Check serum calcium periodically, especially with high doses of calcium or vitamin D.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Calcium gluconate?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium salts can reduce atenolol absorption, which may modestly weaken its heart rate and blood pressure effects. Thiazide-like diuretics such as chlorthalidone reduce urinary calcium excretion, so with calcium supplements they can cause hypercalcemia.
How serious is the interaction between Atenolol-chlorthalidone and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate atenolol and oral calcium doses by at least 2 hours and monitor blood pressure and heart rate. Check serum calcium periodically, especially with high doses of calcium or vitamin D.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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