Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can counteract the effects of amlodipine and is used in calcium channel blocker toxicity. Thiazide diuretics also reduce calcium excretion, which may raise serum calcium.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Raised extracellular calcium opposes L-type calcium channel blockade; thiazides decrease urinary calcium loss.
What to do
Monitor blood pressure and serum calcium during parenteral calcium administration. Adjust antihypertensive therapy if blood pressure control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Calcium gluconate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can counteract the effects of amlodipine and is used in calcium channel blocker toxicity. Thiazide diuretics also reduce calcium excretion, which may raise serum calcium.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium during parenteral calcium administration. Adjust antihypertensive therapy if blood pressure control is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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