Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can reduce the effect of amlodipine and is used in calcium channel blocker overdose. With thiazides, calcium load can also cause hypercalcemia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Increased extracellular calcium counteracts L-type calcium channel blockade; thiazide decreases urinary calcium excretion.
What to do
Monitor blood pressure and serum calcium during parenteral calcium therapy and anticipate reduced amlodipine effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Calcium gluconate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can reduce the effect of amlodipine and is used in calcium channel blocker overdose. With thiazides, calcium load can also cause hypercalcemia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium during parenteral calcium therapy and anticipate reduced amlodipine effect.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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