Drug interactions
Amlodipine-atorvastatin + Calcium gluconate
Severity: Moderate
Amlodipine-atorvastatin and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can reverse the effects of calcium channel blockers, so a bolus may temporarily reduce the blood pressure lowering effect of amlodipine. Oral supplementation has little effect.
What this interaction means in plain words
Amlodipine-atorvastatin and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Raised extracellular calcium competitively overcomes calcium channel blockade by amlodipine.
What to do
Monitor blood pressure when giving intravenous calcium to patients on amlodipine; no change is needed for ordinary oral supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
- Amlodipine-perindopril + Calcium gluconate Moderate
Frequently asked questions
Can I take Amlodipine-atorvastatin with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can reverse the effects of calcium channel blockers, so a bolus may temporarily reduce the blood pressure lowering effect of amlodipine. Oral supplementation has little effect.
How serious is the interaction between Amlodipine-atorvastatin and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when giving intravenous calcium to patients on amlodipine; no change is needed for ordinary oral supplements.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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