Drug interactions
Atenolol-chlorthalidone + Ethacrynic acid
Severity: Moderate
Atenolol-chlorthalidone and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic, and with chlorthalidone it produces strong sequential diuresis. This raises the risk of hypokalemia, hypomagnesemia, hyponatremia, dehydration and hypotension.
What this interaction means in plain words
Atenolol-chlorthalidone and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive inhibition of sodium reabsorption at the loop of Henle and distal tubule with increased potassium and magnesium excretion.
What to do
Monitor electrolytes, renal function, weight and blood pressure, and replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Atenolol-chlorthalidone with Ethacrynic acid?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic, and with chlorthalidone it produces strong sequential diuresis. This raises the risk of hypokalemia, hypomagnesemia, hyponatremia, dehydration and hypotension.
How serious is the interaction between Atenolol-chlorthalidone and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, and replace potassium and magnesium as needed.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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