Drug interactions
Atenolol-chlorthalidone + Gentamicin
Severity: Moderate
Atenolol-chlorthalidone and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal tubular injury with potassium and magnesium wasting, and chlorthalidone adds to electrolyte loss. Diuretic-related volume depletion also increases aminoglycoside nephrotoxicity and may increase ototoxicity risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive electrolyte wasting plus volume depletion that raises aminoglycoside exposure and nephrotoxic risk.
What to do
Monitor renal function, gentamicin levels, potassium and magnesium. Maintain hydration and replace electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Gentamicin?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin can cause renal tubular injury with potassium and magnesium wasting, and chlorthalidone adds to electrolyte loss. Diuretic-related volume depletion also increases aminoglycoside nephrotoxicity and may increase ototoxicity risk.
How serious is the interaction between Atenolol-chlorthalidone and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, gentamicin levels, potassium and magnesium. Maintain hydration and replace electrolytes.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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