Drug interactions
Atenolol-chlorthalidone + Ivabradine
Severity: Moderate
Atenolol-chlorthalidone and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivabradine and atenolol both slow heart rate, so together they raise the risk of symptomatic bradycardia and conduction disturbances. The combination is often used deliberately in heart failure or angina, but careful monitoring is needed.
What this interaction means in plain words
Atenolol-chlorthalidone and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive negative chronotropy: ivabradine inhibits the sinus node If current while atenolol blocks beta-1 receptors.
What to do
Monitor heart rate and ECG, and reduce or stop ivabradine if resting heart rate falls below 50 bpm or symptoms of bradycardia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Ivabradine?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivabradine and atenolol both slow heart rate, so together they raise the risk of symptomatic bradycardia and conduction disturbances. The combination is often used deliberately in heart failure or angina, but careful monitoring is needed.
How serious is the interaction between Atenolol-chlorthalidone and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and reduce or stop ivabradine if resting heart rate falls below 50 bpm or symptoms of bradycardia appear.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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