Drug interactions
Atenolol-chlorthalidone + Lasmiditan
Severity: Moderate
Atenolol-chlorthalidone and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can slow the heart rate, and this effect is additive with beta-blockers such as atenolol. A pharmacokinetic study with propranolol showed an extra decrease in heart rate. The combination is usually tolerable but may cause bradycardia or dizziness.
What this interaction means in plain words
Atenolol-chlorthalidone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive heart rate lowering through pharmacodynamic synergism.
What to do
Monitor heart rate and symptoms of bradycardia after lasmiditan dosing. Use caution in patients with baseline bradycardia or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Lasmiditan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can slow the heart rate, and this effect is additive with beta-blockers such as atenolol. A pharmacokinetic study with propranolol showed an extra decrease in heart rate. The combination is usually tolerable but may cause bradycardia or dizziness.
How serious is the interaction between Atenolol-chlorthalidone and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms of bradycardia after lasmiditan dosing. Use caution in patients with baseline bradycardia or conduction disease.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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