Drug interactions
Amiodarone + Lasmiditan
Severity: Moderate
Amiodarone and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may raise exposure to P-gp substrates such as amiodarone. The clinical significance is uncertain.
What this interaction means in plain words
Amiodarone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, potentially raising amiodarone levels.
What to do
Monitor heart rate and ECG, and watch for amiodarone adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
- Atenolol-chlorthalidone + Lasmiditan Moderate
Frequently asked questions
Can I take Amiodarone with Lasmiditan?
MediHelp rates the interaction as moderate. Amiodarone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may raise exposure to P-gp substrates such as amiodarone. The clinical significance is uncertain.
How serious is the interaction between Amiodarone and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and watch for amiodarone adverse effects.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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