Drug interactions
Aripiprazole + Lasmiditan
Severity: Moderate
Aripiprazole and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, and lasmiditan can impair psychomotor performance. Combined use may increase sedation and impair driving or other tasks.
What this interaction means in plain words
Aripiprazole and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant and sedative effects.
What to do
Advise patients not to drive or operate machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
- Atenolol-chlorthalidone + Lasmiditan Moderate
Frequently asked questions
Can I take Aripiprazole with Lasmiditan?
MediHelp rates the interaction as moderate. Aripiprazole and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, and lasmiditan can impair psychomotor performance. Combined use may increase sedation and impair driving or other tasks.
How serious is the interaction between Aripiprazole and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive or operate machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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