Drug interactions
Asenapine + Lasmiditan
Severity: Moderate
Asenapine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. Lasmiditan has not been formally studied with other CNS depressants.
What this interaction means in plain words
Asenapine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Advise patients to avoid driving or hazardous tasks for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and avoid additional CNS depressants such as alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Atenolol-chlorthalidone + Lasmiditan Moderate
Frequently asked questions
Can I take Asenapine with Lasmiditan?
MediHelp rates the interaction as moderate. Asenapine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. Lasmiditan has not been formally studied with other CNS depressants.
How serious is the interaction between Asenapine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and avoid additional CNS depressants such as alcohol.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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