Drug interactions
Atenolol-chlorthalidone + Lornoxicam
Severity: Moderate
Atenolol-chlorthalidone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam may reduce the antihypertensive effect of atenolol and chlorthalidone. Together with the diuretic it may impair renal function, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis leads to sodium and water retention and reduced renal blood flow.
What to do
Monitor blood pressure and renal function during combined use. Prefer the shortest duration at the lowest NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Lornoxicam
Frequently asked questions
Can I take Atenolol-chlorthalidone with Lornoxicam?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam may reduce the antihypertensive effect of atenolol and chlorthalidone. Together with the diuretic it may impair renal function, particularly in elderly or dehydrated patients.
How serious is the interaction between Atenolol-chlorthalidone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during combined use. Prefer the shortest duration at the lowest NSAID dose.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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