Drug interactions
Celecoxib + Lornoxicam
Severity: Major
Celecoxib and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Lornoxicam is a nonselective NSAID with significant GI toxicity.
What this interaction means in plain words
Celecoxib and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive inhibition of cyclooxygenase, with duplicated effects on gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is made, stop one agent before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Celecoxib with Lornoxicam?
MediHelp rates the interaction as major. Celecoxib and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Lornoxicam is a nonselective NSAID with significant GI toxicity.
How serious is the interaction between Celecoxib and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is made, stop one agent before starting the other.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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