Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Lornoxicam
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam may reduce the antihypertensive effect of valsartan and hydrochlorothiazide and increases the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion that is dependent on angiotensin blockade.
What to do
Avoid regular use where possible, otherwise use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine, and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Lornoxicam
- Ketorolac + Lornoxicam Contraindicated
- Acetylsalicylic acid + Lornoxicam Major
- Amiloride + Lornoxicam Major
- Amlodipine-olmesartan-hydrochlorothiazide + Lornoxicam Major
- Celecoxib + Lornoxicam Major
- Cyclosporin + Lornoxicam Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lornoxicam?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lornoxicam may reduce the antihypertensive effect of valsartan and hydrochlorothiazide and increases the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, particularly in elderly or dehydrated patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible, otherwise use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine, and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
