Drug interactions
Atenolol-chlorthalidone + Losartan
Severity: Moderate
Atenolol-chlorthalidone and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining losartan with atenolol and chlorthalidone produces additive blood pressure lowering, which is often intended but can cause hypotension, especially with volume depletion. Chlorthalidone tends to offset losartan's potassium-raising effect, but renal function and electrolytes can still change.
What this interaction means in plain words
Atenolol-chlorthalidone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through angiotensin receptor blockade, beta-blockade and diuresis, with opposing effects on potassium.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or adjusting doses. Avoid in pregnancy because of fetal toxicity from losartan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Losartan?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining losartan with atenolol and chlorthalidone produces additive blood pressure lowering, which is often intended but can cause hypotension, especially with volume depletion. Chlorthalidone tends to offset losartan's potassium-raising effect, but renal function and electrolytes can still change.
How serious is the interaction between Atenolol-chlorthalidone and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or adjusting doses. Avoid in pregnancy because of fetal toxicity from losartan.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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