Drug interactions
Atenolol-chlorthalidone + Magnesium oxide
Severity: Minor
Atenolol-chlorthalidone and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone increases urinary magnesium loss and can cause hypomagnesemia over time. Magnesium oxide given as a supplement may offset this loss, so the interaction has little adverse consequence.
What this interaction means in plain words
Atenolol-chlorthalidone and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol-chlorthalidone belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide-like diuretics increase renal magnesium excretion.
What to do
No routine action is needed; check serum magnesium in patients on long-term diuretic therapy and adjust the supplement dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Atenolol-chlorthalidone with Magnesium oxide?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone increases urinary magnesium loss and can cause hypomagnesemia over time. Magnesium oxide given as a supplement may offset this loss, so the interaction has little adverse consequence.
How serious is the interaction between Atenolol-chlorthalidone and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check serum magnesium in patients on long-term diuretic therapy and adjust the supplement dose accordingly.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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