Drug interactions
Gemifloxacin + Magnesium oxide
Severity: Moderate
Gemifloxacin and Magnesium oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium oxide binds gemifloxacin in the gut and reduces its absorption. This can result in subtherapeutic antibiotic concentrations and treatment failure.
What this interaction means in plain words
Gemifloxacin and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of gemifloxacin by magnesium cations and antacid effect in the gastrointestinal tract.
What to do
Give gemifloxacin at least 2 hours before or 3 hours after magnesium oxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gentamicin + Magnesium oxide Moderate
Frequently asked questions
Can I take Gemifloxacin with Magnesium oxide?
MediHelp rates the interaction as moderate. Gemifloxacin and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium oxide binds gemifloxacin in the gut and reduces its absorption. This can result in subtherapeutic antibiotic concentrations and treatment failure.
How serious is the interaction between Gemifloxacin and Magnesium oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gemifloxacin at least 2 hours before or 3 hours after magnesium oxide.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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