Drug interactions
Eltrombopag + Magnesium oxide
Severity: Moderate
Eltrombopag and Magnesium oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide, used as an antacid or supplement, can bind eltrombopag in the gut and reduce its absorption, risking diminished platelet response.
What this interaction means in plain words
Eltrombopag and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Magnesium cations chelate eltrombopag in the gastrointestinal tract, reducing absorption.
What to do
Take eltrombopag at least 2 hours before or 4 hours after magnesium-containing antacids or supplements. Monitor platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
- Gentamicin + Magnesium oxide Moderate
Frequently asked questions
Can I take Eltrombopag with Magnesium oxide?
MediHelp rates the interaction as moderate. Eltrombopag and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium oxide, used as an antacid or supplement, can bind eltrombopag in the gut and reduce its absorption, risking diminished platelet response.
How serious is the interaction between Eltrombopag and Magnesium oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take eltrombopag at least 2 hours before or 4 hours after magnesium-containing antacids or supplements. Monitor platelet counts.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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