Drug interactions
Chloroquine + Magnesium oxide
Severity: Moderate
Chloroquine and Magnesium oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids can reduce chloroquine absorption from the gut. This may lead to lower drug levels and reduced efficacy.
What this interaction means in plain words
Chloroquine and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Binding of chloroquine by magnesium and increased gastric pH reduce absorption.
What to do
Separate chloroquine and magnesium oxide by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Magnesium oxide
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
- Gentamicin + Magnesium oxide Moderate
Frequently asked questions
Can I take Chloroquine with Magnesium oxide?
MediHelp rates the interaction as moderate. Chloroquine and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids can reduce chloroquine absorption from the gut. This may lead to lower drug levels and reduced efficacy.
How serious is the interaction between Chloroquine and Magnesium oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate chloroquine and magnesium oxide by at least 4 hours.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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