Drug interactions
Atenolol-chlorthalidone + Mefenamic acid
Severity: Moderate
Atenolol-chlorthalidone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may weaken the antihypertensive effect of atenolol and chlorthalidone. With the diuretic it may also impair renal function, particularly in dehydrated or older patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and reduces renal perfusion.
What to do
Monitor blood pressure and renal function with prolonged use. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Mefenamic acid?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may weaken the antihypertensive effect of atenolol and chlorthalidone. With the diuretic it may also impair renal function, particularly in dehydrated or older patients.
How serious is the interaction between Atenolol-chlorthalidone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function with prolonged use. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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