Drug interactions
Atenolol-chlorthalidone + Mefloquine
Severity: Moderate
Atenolol-chlorthalidone and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia and conduction abnormalities, and combining it with a beta-blocker may increase the risk of bradycardia, heart block or syncope. The labeling advises caution with drugs that slow cardiac conduction.
What this interaction means in plain words
Atenolol-chlorthalidone and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac conduction and heart rate; atenolol is renally cleared so a metabolic interaction is not well established.
What to do
Monitor heart rate and ECG in patients with pre-existing conduction disease or bradycardia. Consider alternative antimalarial if significant bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Atenolol-chlorthalidone with Mefloquine?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause bradycardia and conduction abnormalities, and combining it with a beta-blocker may increase the risk of bradycardia, heart block or syncope. The labeling advises caution with drugs that slow cardiac conduction.
How serious is the interaction between Atenolol-chlorthalidone and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with pre-existing conduction disease or bradycardia. Consider alternative antimalarial if significant bradycardia occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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