Drug interactions
Atenolol-chlorthalidone + Nabumetone
Severity: Moderate
Atenolol-chlorthalidone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone may reduce the antihypertensive effect of atenolol and chlorthalidone. Together with the diuretic it may impair renal function, particularly in older or volume-depleted patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and lowers renal perfusion.
What to do
Monitor blood pressure and renal function with ongoing use. Use the lowest effective dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Nabumetone?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone may reduce the antihypertensive effect of atenolol and chlorthalidone. Together with the diuretic it may impair renal function, particularly in older or volume-depleted patients.
How serious is the interaction between Atenolol-chlorthalidone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function with ongoing use. Use the lowest effective dose for the shortest duration.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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