Drug interactions
Atenolol-chlorthalidone + Piroxicam
Severity: Moderate
Atenolol-chlorthalidone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the antihypertensive efficacy of atenolol and chlorthalidone. Combined with a diuretic it increases the risk of renal impairment, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and fluid retention and reduces renal perfusion.
What to do
Monitor blood pressure and renal function during combined use. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Piroxicam?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the antihypertensive efficacy of atenolol and chlorthalidone. Combined with a diuretic it increases the risk of renal impairment, especially in elderly or volume-depleted patients.
How serious is the interaction between Atenolol-chlorthalidone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during combined use. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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