Drug interactions
Atenolol-chlorthalidone + Tizanidine
Severity: Moderate
Atenolol-chlorthalidone and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure and heart rate. Combined with a beta-blocker and a thiazide-like diuretic, hypotension and bradycardia may be more pronounced, with dizziness or syncope in some patients.
What this interaction means in plain words
Atenolol-chlorthalidone and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic blood pressure lowering through central sympatholytic action plus beta-blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or increasing tizanidine, and counsel patients about orthostatic dizziness. Reduce the tizanidine dose or adjust antihypertensives if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Tizanidine?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure and heart rate. Combined with a beta-blocker and a thiazide-like diuretic, hypotension and bradycardia may be more pronounced, with dizziness or syncope in some patients.
How serious is the interaction between Atenolol-chlorthalidone and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or increasing tizanidine, and counsel patients about orthostatic dizziness. Reduce the tizanidine dose or adjust antihypertensives if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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