Drug interactions
Atidarsagene autotemcel + Nevirapine
Severity: Major
Atidarsagene autotemcel and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antiretrovirals may interfere with manufacture of the gene-modified cell product by impairing transduction of the harvested cells. Nevirapine therefore needs to be stopped before mobilization and apheresis.
What this interaction means in plain words
Atidarsagene autotemcel and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Nevirapine belongs to Anti Virals.
Why it happens
Antiretroviral activity may inhibit lentiviral vector transduction during manufacturing of the cell product.
What to do
Discontinue nevirapine at least one month before mobilization, or longer to allow elimination, and until apheresis is complete. Plan an alternative HIV approach with the treating team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atidarsagene autotemcel and Nevirapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Nevirapine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals may interfere with manufacture of the gene-modified cell product by impairing transduction of the harvested cells. Nevirapine therefore needs to be stopped before mobilization and apheresis.
How serious is the interaction between Atidarsagene autotemcel and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue nevirapine at least one month before mobilization, or longer to allow elimination, and until apheresis is complete. Plan an alternative HIV approach with the treating team.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
