Drug interactions
Atogepant + Diltiazem
Severity: Moderate
Atogepant and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem, a moderate CYP3A4 inhibitor, can raise atogepant exposure and increase adverse effects such as constipation, nausea and fatigue.
What this interaction means in plain words
Atogepant and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of atogepant by diltiazem.
What to do
Limit atogepant to the lower dose recommended with CYP3A4 inhibitors when used for migraine prevention, and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Diltiazem?
MediHelp rates the interaction as moderate. Atogepant and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem, a moderate CYP3A4 inhibitor, can raise atogepant exposure and increase adverse effects such as constipation, nausea and fatigue.
How serious is the interaction between Atogepant and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the lower dose recommended with CYP3A4 inhibitors when used for migraine prevention, and monitor tolerability.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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