Drug interactions
Atogepant + Griseofulvin
Severity: Moderate
Atogepant and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and griseofulvin as a CYP3A4 inducer may reduce its concentrations. Lower exposure could decrease migraine prevention efficacy.
What this interaction means in plain words
Atogepant and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Griseofulvin belongs to Anti Fungals.
Why it happens
CYP3A4 induction by griseofulvin increases atogepant metabolism.
What to do
Monitor migraine control; atogepant labeling advises dose adjustment with strong inducers, so consider an alternative to griseofulvin or review atogepant dosing if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Griseofulvin?
MediHelp rates the interaction as moderate. Atogepant and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atogepant is a CYP3A4 substrate, and griseofulvin as a CYP3A4 inducer may reduce its concentrations. Lower exposure could decrease migraine prevention efficacy.
How serious is the interaction between Atogepant and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor migraine control; atogepant labeling advises dose adjustment with strong inducers, so consider an alternative to griseofulvin or review atogepant dosing if efficacy falls.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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