Drug interactions
Atogepant + Isoniazid
Severity: Moderate
Atogepant and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP3A4, which may raise atogepant exposure. Isoniazid is not a classic strong inhibitor so the effect is probably smaller than with agents such as ketoconazole.
What this interaction means in plain words
Atogepant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by isoniazid reduces atogepant metabolism.
What to do
Monitor for atogepant adverse effects such as constipation, nausea and fatigue. Consider limiting atogepant to 10 mg daily if a strong inhibitory effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Isoniazid?
MediHelp rates the interaction as moderate. Atogepant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP3A4, which may raise atogepant exposure. Isoniazid is not a classic strong inhibitor so the effect is probably smaller than with agents such as ketoconazole.
How serious is the interaction between Atogepant and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for atogepant adverse effects such as constipation, nausea and fatigue. Consider limiting atogepant to 10 mg daily if a strong inhibitory effect is suspected.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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