Drug interactions
Atogepant + Metronidazole
Severity: Minor
Atogepant and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is at most a weak CYP3A4 inhibitor, so a clinically significant rise in atogepant exposure is unlikely. Atogepant is a CYP3A4 substrate, but only strong inhibitors require dose limits.
What this interaction means in plain words
Atogepant and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole slightly reducing atogepant metabolism.
What to do
No dose adjustment is required; monitor for increased atogepant adverse effects such as nausea, constipation and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Metronidazole?
MediHelp rates the interaction as minor. Atogepant and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is at most a weak CYP3A4 inhibitor, so a clinically significant rise in atogepant exposure is unlikely. Atogepant is a CYP3A4 substrate, but only strong inhibitors require dose limits.
How serious is the interaction between Atogepant and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for increased atogepant adverse effects such as nausea, constipation and fatigue.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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