Drug interactions
Atogepant + Phenytoin
Severity: Moderate
Atogepant and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin is a strong CYP3A4 inducer, and atogepant is a CYP3A4 substrate. Co-administration lowers atogepant exposure and may reduce its migraine preventive efficacy.
What this interaction means in plain words
Atogepant and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing atogepant metabolism.
What to do
Adjust atogepant to the labeled dose for use with CYP3A4 inducers (30 mg or 60 mg daily for episodic migraine, with use of a 60 mg daily dose in chronic migraine). Monitor migraine control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Phenytoin?
MediHelp rates the interaction as moderate. Atogepant and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin is a strong CYP3A4 inducer, and atogepant is a CYP3A4 substrate. Co-administration lowers atogepant exposure and may reduce its migraine preventive efficacy.
How serious is the interaction between Atogepant and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust atogepant to the labeled dose for use with CYP3A4 inducers (30 mg or 60 mg daily for episodic migraine, with use of a 60 mg daily dose in chronic migraine). Monitor migraine control.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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