Drug interactions
Atomoxetine + Bupropion-naltrexone
Severity: Moderate
Atomoxetine and Bupropion-naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion increases atomoxetine concentrations via CYP2D6 inhibition, which may increase heart rate, blood pressure and insomnia. Both drugs can also lower the seizure threshold.
What this interaction means in plain words
Atomoxetine and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Bupropion-naltrexone belongs to Miscellaneous.
Why it happens
CYP2D6 inhibition by bupropion reduces atomoxetine clearance.
What to do
Start atomoxetine at a lower dose and titrate; monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Bupropion-naltrexone?
MediHelp rates the interaction as moderate. Atomoxetine and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion increases atomoxetine concentrations via CYP2D6 inhibition, which may increase heart rate, blood pressure and insomnia. Both drugs can also lower the seizure threshold.
How serious is the interaction between Atomoxetine and Bupropion-naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start atomoxetine at a lower dose and titrate; monitor heart rate and blood pressure.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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