Drug interactions
Atomoxetine + Dacomitinib
Severity: Major
Atomoxetine and Dacomitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, the main enzyme that clears atomoxetine. Atomoxetine exposure may rise to levels like those in CYP2D6 poor metabolisers, increasing adverse effects such as hypertension, tachycardia and insomnia.
What this interaction means in plain words
Atomoxetine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Dacomitinib belongs to Oncology.
Why it happens
Dacomitinib inhibits CYP2D6, reducing atomoxetine metabolism.
What to do
Start atomoxetine at the lower dose and increase only if tolerated, or choose an alternative. Monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
- Dacomitinib + Dexlansoprazole Major
Frequently asked questions
Can I take Atomoxetine with Dacomitinib?
MediHelp rates the interaction as major. Atomoxetine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, the main enzyme that clears atomoxetine. Atomoxetine exposure may rise to levels like those in CYP2D6 poor metabolisers, increasing adverse effects such as hypertension, tachycardia and insomnia.
How serious is the interaction between Atomoxetine and Dacomitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start atomoxetine at the lower dose and increase only if tolerated, or choose an alternative. Monitor heart rate and blood pressure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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